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Comparison of ChTS bound to 17 (green/navy) and ChTS bound to 24 (dark green/teal) with dUMP (yellow) (PDB: 6PFF, and 6PFH). A. Comparison of 17 and 24 bound in ChTS active site, hydrogen bonds to 17 in gray and to 24 in black. B. Zoom in view rotation of 24 2-phenylacetic acid moiety with respect to 17 benzoic acid moiety. C. Zoom in view of shift of pyrrolo[2,3-d]pyrimidine moiety of 17 and 24.
