Skip to main content
. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Neuromolecular Med. 2019 May 4;21(4):325–343. doi: 10.1007/s12017-019-08537-7

Figure 2. THSD1/FAK signaling with its downstream targets.

Figure 2.

THSD1 is required for normal levels of focal adhesions and THSD1 loss reduces the overall amount of focal adhesions, FAK, and active phosphorylated FAK in endothelial cells. As a result, several pathways may be implicated including SRC, PI3K/AKT, Rho, and Rac1 signaling that affects actin cytoskeleton organization and cell adhesion mediated in part through integrins and mechanosensors.