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. 2019 Sep 18;19(5):e30. doi: 10.4110/in.2019.19.e30

Table 1. Regulation of host miRs during M. tuberculosis infections.

miRNAs Species Targets Biological outcome Reference
miR-20a-5p M. tuberculosis JNK-2 Inhibition of apoptosis (61)
miR-21 M. tuberculosis MPT64 Bcl-2 Inhibits apoptosome formation (63)
miR-125b M. tuberculosis TNF Destabilises TNF-α miR (59)
miR99b M. tuberculosis TNF and TNF-α receptor Lowers production of TNF-α and TNF-α receptor (58)
miR-582-5p M. tuberculosis FOXO1 Inhibits activation of multiple pro-apoptotic genes (64)
miR-155 M. tuberculosis FOXO3 Inhibition of apoptosis (66)
miR-223 M. tuberculosis FOXO3 Inhibition of apoptosis (65)
miR-27b M. tuberculosis Bag2 p53 dependent apoptosis (62)
hsa-let-7b-5p M. tuberculosis Fas protein M. tuberculosis survival in THP-1 cells (60)
miR-155 M. tuberculosis Atg3 Reduced autolysosome fusion and decrease autophagosome number (92)
miR-142-3p M. tuberculosis N-WASP Deregulation of actin dynamics during phagocytosis (90)
miR-99b M. tuberculosis strain H37Rv TNF-α TNF-α, IL-6, IL-12, and IL-1 (58)
miR-223 M. tuberculosis p65 phosphorylation, CXCL2, CCL3 and IL-6 NF-κB, TNF-α and IL-6 and IL-12p40, chemotaxis (107,108)
Let-7f M. tuberculosis A20 Reduced production of IL-1β, TNF-α, and NO (106)
miR-26a and miR-132 M. tuberculosis P300 Inhibition of IFN-γ signalling cascade (115)
miR-29 M. tuberculosis IFN-γ Regulates Th1 response (114)
miR-125b M. tuberculosis lipomannan TNF-α Regulates Th1 response (59)
miR-144* M. tuberculosis TNF-α, IFN-γ Cytokine signalling and cell proliferation (116)
miR-1178 M. tuberculosis TLR-4 IFN-γ, IL-6, IL-1 and TNF-α (117)
miR-106b-5p M. tuberculosis CtsS mRNA Reduced T cell activation and HLA-DR expression (124)