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. 2019 Sep 18;19(5):e30. doi: 10.4110/in.2019.19.e30

Table 2. miR-mediated modulation of host immune response during M. bovis and other mycobacterial infections.

miRs Species Target Biological outcome Reference
miR-203 M. bovis BCG MyD88 Inhibits production of NF-κB, TNF-α, and IL-6 (101)
miR-149 M. bovis BCG MyD88 Reduced production of NF-κB, TNF-α, and IL-6 (103)
miR-124 M. bovis BCG TLR6, MyD88, TRAF-6, TNF-α Blocks inflammatory response (96)
miR-31 and miR-150 M. bovis BCG MyD88 Interferes with TLR2 signalling (101,102)
miR-142-3p M. bovis BCG IRAK-1 NF- κB, TNF-α, and IL-6 (91)
miR-146a M. bovis BCG IRAK-1 and TRAF-6 Reduces activation of NF-κB and MAPK signalling, PTGS2, suppresses NO production (97)
miR-146a M. bovis BCG IFN-γ Autoimmune disease involving STAT1 pathway (113)
miR-21 M. bovis BCG IL-12p35 mRNA Inhibits IL-12 production (105)
miR-155 M. marium CEBP Inhibits production NO synthase (69)
Let-7a and miR-29a M. avium Caspase 3 and 7 Inhibition of apoptosis (10)
miR-142-3p M. smegmatis N-WASP Deregulation of actin dynamics during phagocytosis (91)
miR-125b M. smegmatis TNF Inhibition of TNF-α, IL-6, IL-12, and IL-1 production (58)
miR-21 M. leprae CAMP, DEFB4 Inhibition of vitamin D dependent anti-microbial pathway (118)