Table 1. Phenotypes detected in 16GsoT/T mice compared with those identified in published KO mutants, AUTS2 syndrome, and ASD human patients.

Phenotype	16Gso T/T	Sox1 −/−a,b	Auts2−/−c	Auts2-/+d	Auts2-T1−/−e	Related phenotypes in AUTS2 or ASD patientsf
Small size, low postnatal growth	+	—	nr	+	+	Low birth weight, short stature
Delayed righting	+	nr	.	+	nr	Developmental delay
Learning and memory deficits	+	—	.	+	nr	Intellectual disability
Cortical layering defects	—	—	+	-	nr	Intellectual disability
Abnormal skull/nose length	+	—	nr	nr	nr	Dysmorphic features
Freezing behavior, anxiety	+	+	.	nr	nr	Adverse response to novelty, anxiety
Reduced exploratory activity	+	nr	.	+	nr	Intellectual disability
Abnormal nesting	+	nr	.	nr	nr	Abnormal social behavior
Repetitive grooming behaviors	+	—	.	nr	nr	Stereotypic behavior, obsessive compulsive behavior
Seizures	+	+	.	nr	nr	Epilepsyf,g
Abnormal Purkinje Cell differentiation	+	—	.	nr	nr	ASDh
Abnormal Purkinje Cell dendrites	+	—	.	nr	nr	ASDh
Purkinje Cell loss	+	—	.	nr	nr	ASDh
Abnormal numbers and packing of hippocampal neurons	+	—	.	nr	nr	ASDh

⁺in each column denotes that the phenotype has been observed; - denotes that the phenotype was investigated but not detected; nr = not reported; . = not applicable (animals die around the time of birth).

Data taken from ^aMalas et al., 2003

^bSottile et al., 2006

^cHori et al., 2014

^dHori et al., 2016

^eGao et al., 2014

^fSummarized from (Beunders et al. 2013) unless otherwise noted

^g(Sultana et al. 2002)

^h(Amaral et al. 2008).