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. 2019 Jun 21;4(10):1373–1386. doi: 10.1016/j.ekir.2019.06.005

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© 2019 International Society of Nephrology. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Kaplan-Meier curves of new-onset microalbuminuria in patients with type 2 diabetes mellitus at overall (a) and according to quartiles of C-X-C motif chemokine ligand 16 (CXCL-16) (b), transforming growth factor-β1 (TGF-β1) (c), and angiopoietin-2 (d) at baseline after adjusting for age, sex, body mass index, duration of diabetes, smoking status, mean blood pressure, glycated hemoglobin, estimated glomerular filtration rate, low-density lipoprotein, time of follow-up, urine albumin-to-creatinine ratio, and cardiac complications. The upper quartiles of the above 3 biomarkers are associated with an increased incidence of de novo microalbuminuria. The differences were statistically significant in comparison with the lower quartile.

Kaplan-Meier curves of new-onset microalbuminuria in patients with type 2 diabetes mellitus at overall (a) and according to quartiles of C-X-C motif chemokine ligand 16 (CXCL-16) (b), transforming growth factor-β1 (TGF-β1) (c), and angiopoietin-2 (d) at baseline after adjusting for age, sex, body mass index, duration of diabetes, smoking status, mean blood pressure, glycated hemoglobin, estimated glomerular filtration rate, low-density lipoprotein, time of follow-up, urine albumin-to-creatinine ratio, and cardiac complications. The upper quartiles of the above 3 biomarkers are associated with an increased incidence of de novo microalbuminuria. The differences were statistically significant in comparison with the lower quartile.