Table 3.
Univariate analysis | ||
---|---|---|
Risk factors | Hazard ratio (95% CI) after adjusting for baseline GFR | P value |
Nonmodifiable risk factors | ||
Glomerular disease | 2.59 (1.07, 6.27) | 0.034 |
eGFR at baseline | 3.3 (1.3, 8.4) | 0.001 |
Modifiable risk factors | 0.56 | |
Proteinuria | 3.1 (1.3, 7.2) | 0.009 |
Hypertension | 1.4 (0.43, 4.9) | 0.56 |
Anemia | 4.08 (1.8, 9.26) | 0.001 |
Calcium level | 0.3 (0.19, 0.487) | <0.001 |
Phosphate level | 2.09 (1.36, 3.22 | 0.001 |
Parathormone level | 1.004 (1.002, 1.005) | <0.001 |
Height z score | 0.75 (0.6, 0.9) | 0.006 |
Metabolic acidosis | 3.05 (0.91, 10.2) | 0.071 |
Multivariate analysis | ||
Glomerular disease | 2.7 (1.1, 6.3) | 0.032 |
eGFR at baseline | 3.39 (1.3, 8.8) | 0.005 |
Proteinuria (baseline) | 1.04 (1.01, 1.07) | 0.009 |
Proteinuria on follow-up | 1.4 (1.2, 1.52) | 0.005 |
Uncontrolled hypertension at last follow-upa | 2.53 (1.01, 6.77) | 0.04 |
Uncontrolled hypertension at last follow-up + proteinuriaa | 4.2 (1.85. 9.63) | 0.001 |
CI, confidence interval; eGFR, estimated glomerular filtration rate; GFR, glomerular filtration rate.
Numbers in bold indicate statistically significant risk factors.
Uncontrolled hypertension is defined as blood pressure above the 95th centile for age and sex despite medications.