Table 1.

Summary of VEGF-ECM Antagonists.

Reagent	Mode of Action	Expected Impact
Fc-VEGF-R2	Binds to VEGF in the ECM.	Block VEGF-R2 binding site on VEGF. Specifically prevents VEGF-R2 on RECs from engaging VEGF in the ECM.
sFn	Competes for VEGF specifically bound to Fn.	Binds and releases VEGF from Fn and into soluble VEGF-sFn form. Reduces sites for VEGF-R2 on RECs to bind in the ECM.
SOS	Binds to VEGF and blocks its binding to Fn.	Reduces VEGF-Fn complexes. Reduces sites for VEGF-R2 on RECs to bind in the ECM.