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. 2019 Oct 9;20(20):4983. doi: 10.3390/ijms20204983

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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RNA sequencing (RNA-seq) profiling identifies significant transcriptional changes in drug treated bladder PDX tumors. (A) 351 and 402 genes were found significantly changed in BL0293 and BL0440 drug-relapsed tumors; (B) 20 up-regulated and (D) 17 down-regulated genes where shared by both drug-relapsed xenografts. (C) A heat map depicts variation of shared up- and down-regulated genes among BL0293 and BL0440 biological replicates. M1 and M2 denote biological replicates. (E) methionine adenosyltransferase 1a (MAT1A) gene expression values in sensitive (PBS) and drug treated (Rx) tumors from RNA sequencing data, expressed in fold change (FC), for both BL0293 and BL0440.