Table 1.
Significantly changed inflammatory factors that were regulated by Met and PTA; authenticated by ELISA.
| Kidney (pg/mgprot) | db/m+ | db/db | db/db | ||
|---|---|---|---|---|---|
| Met (0.1g/kg) | PTA (0.025g/kg) | PTA (0.1g/kg) | |||
| IL-2 | 54.8 ± 2.5 | 72.4 ± 9.3## | 59.7 ± 6.9* | 53.6 ± 3.9** | 59.4 ± 7.0* |
| IL-4 | 2.7 ± 0.1 | 2.4 ± 0.1# | 2.9 ± 0.3** | 2.8 ± 0.3** | 3.0 ± 0.5** |
| IL-12 | 0.80 ± 0.08 | 1.35 ± 0.14### | 0.93 ± 0.11*** | 0.96 ± 0.09*** | 1.05 ± 0.06** |
| TNF-α | 100.2 ± 6.7 | 132.7 ± 11.7## | 116.1 ± 14.0 | 100.7 ± 10.0** | 102.4 ± 4.3** |
| LEP | 0.66 ± 0.05 | 0.37 ± 0.02### | 0.65 ± 0.04*** | 0.65 ± 0.09*** | 0.66 ± 0.09*** |
| M-CSF | 21.2 ± 1.9 | 26.1 ± 0.6## | 20.9 ± 1.6** | 18.9 ± 2.2*** | 20.9 ± 1.9** |
| IFN-γ | 2.5 ± 0.3 | 3.4 ± 0.2## | 2.4 ± 0.2*** | 2.2 ± 0.1*** | 2.7 ± 0.2** |
Data are expressed as mean ± SD (n = 12). # p < 0.05, ## p < 0.01 and ### p < 0.001 vs. db/m+ mice, * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. non-treated db/db mice.