Table A1.
The effects of Met and PTA on the changes in bodyweight, plasma glucose, and food and water intake of mice.
| Week | db/m+ | db/db | db/db | |||
|---|---|---|---|---|---|---|
| Met (100 mg/kg) | PTA (25 mg/kg) | PTA (100 mg/kg) | ||||
| Body weights (g) | 1 | 20.4 ± 2.2 | 41.6 ± 2.3### | 40.6 ± 2.9 | 40.8 ± 3.0 | 40.3 ± 2.6 |
| 2 | 18.4 ± 2.5 | 42.7 ± 2.6### | 39.3 ± 3.2* | 40.0 ± 3.0* | 40.1 ± 2.4* | |
| 3 | 20.3 ± 2.1 | 45.4 ± 1.9### | 42.9 ± 3.0* | 41.8 ± 2.8** | 42.6 ± 1.8** | |
| 4 | 21.4 ± 1.1 | 46.6 ± 2.2### | 43.8 ± 3.7* | 43.8 ± 2.9* | 44.3 ± 2.1* | |
| 5 | 22.1 ± 0.9 | 48.8 ± 2.9### | 45.4 ± 2.9* | 45.3 ± 2.4** | 46.0 ± 2.1* | |
| 6 | 22.0 ± 0.8 | 51.5 ± 2.6### | 45.9 ± 3.1** | 45.6 ± 3.2*** | 46.9 ± 2.1** | |
| 7 | 23.0 ± 0.8 | 51.1 ± 3.2### | 45.3 ± 3.0** | 45.9 ± 2.9** | 47.8 ± 2.4* | |
| 8 | 22.7 ± 1.4 | 51.1 ± 3.1### | 45.5 ± 1.9*** | 46.1 ± 2.7** | 48.0 ± 2.8* | |
| Plasma glucose (mmol/L) | 1 | 5.0 ± 2.3 | 17.0 ± 6.2### | 16.9 ± 6.4 | 15.6 ± 6.5 | 17.9 ± 3.5 |
| 2 3 |
6.6 ± 1.3 6.8 ± 1.6 |
20.4 ± 3.8### 20.2 ± 3.9### |
17.8 ± 3.3 18.8 ± 3.2 |
16.6 ± 3.6* 17.3 ± 2.1 |
17.9 ± 1.7 17.4 ± 2.3 |
|
| 4 5 |
6.7 ± 0.9 6.8 ± 0.8 |
20.3 ± 3.9### 21.0 ± 3.6### |
19.0 ± 1.1 17.3 ± 2.9* |
18.1 ± 3.2 17.6 ± 3.1 |
17.2 ± 2.5* 16.7 ± 2.3** |
|
| 6 7 |
6.1 ± 1.0 7.0 ± 1.3 |
21.2 ± 2.2### 21.7 ± 2.2### |
17.2 ± 2.3** 17.8 ± 2.6** |
18.9 ± 2.3* 18.9 ± 2.7* |
16.2 ± 2.7*** 16.1 ± 2.1*** |
|
| 8 | 6.7 ± 0.7 | 23.4 ± 2.3### | 17.1 ± 2.0*** | 17.4 ± 3.0*** | 16.4 ± 2.2*** | |
Data are expressed as mean ± SD (n = 12). ### p < 0.001 vs. db/m+ mice, * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. non-treated db/db mice.