Table 1.
Body weight and composition variations according to obesity-treated groups.
| ND-EX Control | HFD-ND | HFD-ND EX | HFD-ND GW | HFD-ND EX GW | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| ΔBW (T1−T0) (g) | 1.68 | 1.19 | −2.33 | 1.08 | −2.28 | 1.42 | −6.2 # | 2.86 | −4.4 # | 1.98 | |
| Adipose tissues (mg/g) | Subcutaneous | 17.29 | 3.73 | 21.98 $ | 6.74 | 14.61 * | 2.43 | 14.33 * | 2.86 | 14.67 * | 4.21 |
| Visceral | 12.55 | 3.36 | 21.12 $ | 7.16 | 11.41 * | 3.33 | 11.77 * | 1.10 | 10.93 * | 3.08 | |
| Brown | 3.50 | 1.17 | 3.54 | 0.63 | 2.98 | 0.27 | 3.32 | 0.42 | 2.85 | 0.44 | |
| Skeletal muscles (mg/g) | TLA | 1.87 | 0.74 | 1.45 | 0.18 | 1.65 | 0.08 | 1.59 | 0.06 | 1.56 | 0.11 |
| Vastus lateralis | 6.88 | 0.48 | 6.40 | 0.37 | 7.03 | 0.24 | 6.83 | 0.64 | 7.27 * | 0.41 | |
| Soleus | 0.28 | 0.02 | 0.26 | 0.02 | 0.33 | 0.05 | 0.33 | 0.15 | 0.27 | 0.05 | |
Mice were fed a Normal chow Diet (ND) (n = 6) or High Fat Diet (HFD) (n = 24) for 12 weeks. At T0, they all received a ND for 8 weeks. HFD mice were then randomly assigned in one of four groups: only return to ND (HFD-ND, n = 6), return to ND plus exercise training (HFD-ND-EX, n = 6), return to ND plus PPARβ/δ agonist GW0742 treatment (HFD-ND-GW, n = 6), or return to ND plus combined treatment (HFD-ND-EX-GW, n = 6). ND fed mice were maintained on a ND and were trained to be considered as a “healthy” reference group (ND-EX, n = 6). Data are expressed as mean ± SD. * p < 0.05 vs. HFD-ND and # p < 0.05 GW0742 effect (2-way ANOVA); $ p < 0.05 vs. ND-EX (one-way ANOVA).