3D	three-dimensional
[15]pyN5	3,6,9,12,18-pentaazabicyclo[1 2.3.1]octadeca-1(18),14,16-triene
[16]pyN5	3,6,10,13,19-pentaazabicyclo[13.3.1]nonadeca-1(19),15,17-triene
AHA	acetohydroxamic acid
ARP-100	2-[([1,1′-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxyacetamide
CM2D	Conditioned medium from 2D models
CM3D	Conditioned medium from 3D models
DMEM	Dulbecco modified eagle modified medium
DMSO	dimethylsulfoxide
EDTA	ethylenediaminetetraacetic acid
ECM	extracellular matrix
EMT	epithelial to mesenchymal transition
FBS	fetal bovine serum
H&E	hematoxylin and Eosin
MMPi	MMP inhibitor(s)
MMPs	matrix metalloproteinases
MSS	musculoskeletal syndrome
MTS	tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4- sulfophenyl)-2H-tetrazolium
PAGE	polyacrylamide gel electrophoresis
Py-macrocyles	pyridine containing macrocycles
SDS	sodium dodecyl sulfate
TIMPs	tissue inhibitors of matrix metalloproteinase
ULA	ultra low attachment