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Model for leptin-induced EMT via Src and FAK signaling pathways. Leptin activates FAK and Src in a positive feedback pathway, which in turn regulate the expression and subcellular localization of β-catenin and Twist, promoting the expression of MMP-2 and MMP-9 as well as EMT-related events such as invadopodia formation and cell invasion. ? indicates an unknown mechanism.
