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. 2019 Sep 20;8(10):1112. doi: 10.3390/cells8101112

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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HtrA4 decreases the viability of cancer cells. The assay was performed using the A549 cells with exogenous HtrA4 and ΔN-HtrA4, induced by adding doxycycline to the medium (A) and the A549 and MCF7 cells with downregulated HtrA4 expression (B). The survival is presented as a percent of live cells containing exogenous HtrA4 (induced by doxycycline) versus not containing HtrA4 (not induced by doxycycline). For more clarity, only the data of the A549 transduced with pTW_H4 noninduced control cells are presented (in A). Viability of cancer cells was analyzed using MTT and SRB assays. Data correspond to mean ± SD of at least five experiments. p-value < 0.05 (*), 0.01 (**), or 0.001 (***).