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HtrA4 reduces the clonogenic potential of cancer cells. The A549 cells with inducible expression of the HtrA4 or ΔN-HtrA4 genes (A) and the A549 and MCF7 cells with downregulated HtrA4 expression (B) were treated with a chemotherapeutic for 24 h, and the clonogenic potential was assayed. The colonies were stained by crystal violet (Figure S3), and quantitative results are shown as mean ± SD of three independent experiments. p-value < 0.05 (*), 0.01 (**), or 0.001 (***).
