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. 2019 Sep 26;8(10):1153. doi: 10.3390/cells8101153

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Changes in rat fecal microbiota by oleanolic acid and anagliptin. (A) Comparative analysis of Chao1 richness and Shannon diversity in fecal microbiome of the experimental groups. (B) The ratio of Firmicutes:Bacteroidetes (F/B) at the phylum level in the experimental groups. (C) Univariate correlation analysis between the ratio of F/B and the values of HOMA–IR in the experimental OLETF rats. (D) Relative abundances of Bacteroides, Prevotella, Ruminococcus, and Lactobacillus at the genus level in the experimental group. Ctr; negative control group, Veh; vehicle-treated PS-injected group, OA; oleanolic acid-treated PS-injected group, ANA; anagliptin-treated PS-injected group, Both; oleanolic acid and anagliptin-treated PS-injected group. Data are means ± SD (n = 5). *, P ≤ 0.05.