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Co-signaling axes of DC involved in SLE. As the main producer of type I interferon, pDC is known to be regulated by co-inhibitory axes including BDCA2. Other co-inhibitory axes (red line) of DC also inhibit the immune responses that may be linked to SLE. DC: dendritic cell; pDC: plasmacytoid dendritic cell; BDCA2: Blood-derived dendritic cell antigen 2; ILT4: immunoglobulin-like transcripts 4; ILT2: immunoglobulin-like transcripts 2; LAIR-1: leukocyte-associated Ig-like receptor 1.
