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. 2019 Sep 23;8(10):1131. doi: 10.3390/cells8101131

Figure 2.

Figure 2

Schematic representation of the role of inflammasome in different experimental models of warm I/R injury. (A) Experimental models of 30 (A.1), 60 (A.2) and 90 (A.3) minutes of warm ischemia-reperfusion injury without hepatic resection. (B) Experimental models of partial hepatectomy without ischemia-reperfusion. (C) Experimental models of partial hepatectomy with 45 min of warm ischemia-reperfusion injury. Abbreviations: AKT, Protein kinase B; AP-1, Activator protein 1; ASC, Apoptosis-associated speck-like protein containing a CARD; BHB, β-hydroxybutyric acid; Cat B, Cathepsin B; Dex, Dexmedetomidine; DHA, Docosahexaenoic acid; FOXO1, Forkhead box protein O1; HMGB1, High mobility group box 1; HO-1, Heme oxygenase 1; HSF1, Heat shock transcription factor 1; IL, Interleukin; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRC4, NLR family CARD domain-containing protein 4; NLRP3, NLR pyrin domain containing protein 3; Nrf2, Nuclear factor erythroid 2-related factor 2; Panx1 Inh, Pannexin-1 inhibitor; RAP1, Repressor activator protein 1; STAT3, Signal transducer and activator of transcription 3; T3, 3,3’,5-triiodothyronine; TLR4, Toll-like receptor 4; TNF, Tumor necrosis factor; XBJ, Xuebijing; XBP1, X-box-binding protein 1.