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. 2019 Sep 27;151(11):1287–1299. doi: 10.1085/jgp.201912419

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© 2019 Fain et al.

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Figure 5. — Flash and step responses from WT cones and cones lacking recoverin and/or the GCAPs. Photocurrents were recorded from transgenic mouse cones: Gnat1^−/− (A and B), Gnat1^−/−;Rv^−/− (C and D), Gnat1^−/−;Gcaps^−/− (E and F), and Gnat1^−/−;Rv^−/−;Gcaps^−/− (G and H). Stimulus onset was at time = 0 ms. The left column shows current responses from individual, representative cones when exposed to brief flashes of increasing strength (in P*/flash): Gnat1^−/− 63–15,000; Gnat1^−/−;Rv^−/− 190–39,000; Gnat1^−/−;Gcaps^−/− 76–9,400; Gnat1^−/−;Rv^−/−; Gcaps^−/− 81–7,770. Traces are averages of three to five traces/flash strength. In the right column, the same cones were stimulated with 5 s of steady light at increasing intensities (in P*/s): Gnat1^−/− 3,400–1.5 × 10⁶; Gnat1^−/−;Rv^−/− 3,700–4.0 × 10⁶; Gnat1^−/−;Gcaps^−/− 4,900–1.03 × 10⁶; Gnat1^−/−;Rv^−/−;Gcaps^−/− 7,500–64,000. Each steady-light intensity was presented two times to limit pigment bleaching.