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. 2019 Sep 27;151(11):1287–1299. doi: 10.1085/jgp.201912419

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© 2019 Fain et al.

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Figure 6. — Kinetics and sensitivity changes occur when transduction proteins are lost. (A) Intensity–response relations for the steady-state current response normalized to the peak steady-state current response are plotted against stimulus intensity and fit with Eq. 1. (B) The percentage of current recovery (i.e., percentage of channels reopening) was calculated as the difference between the peak and steady-state currents divided by the peak current. Gnat1^−/− and Gnat1^−/−;Rv^−/− cones quickly recovered a large fraction of their initial dark current (30–50%) before reaching steady-state. Gcaps^−/− cones recovered much less dark current (∼20%) Error bars represent SEM.