Table 1. Figure 2 electrophysiological measurements segregated by sex.
Measure | WT | NaVβ4−/− | WT | NaVβ4Δp/Δp | ||||
---|---|---|---|---|---|---|---|---|
M (n = 4) | F (n = 2) | M (n = 2) | F (n = 6) | M (n = 6) | F (n = 3) | M (n = 6) | F (n = 3) | |
Gmax (nS) | 78.5 ± 8.1 | 107.2 ± 3 | 61.4 ± 0.18 | 61.5 ± 8.1 | 74.8 ± 8.5 | 44.7 ± 11 | 61.8 ± 5.8 | 76.1 ± 1.2 |
V1/2 activation (mV) | −34 ± 2.6 | −42 ± 6.3 | −37.5 ± 3.5 | −35.3 ± 0.6 | −39.1 ± 3.2 | −37.1 ± 1.9 | −37.2 ± 1.3 | −40.3 ± 0.6 |
k activation (mV) | 5.97 ± 0.21 | 6.56 ± 1.53 | 6.13 ± 0.99 | 5.90 ± 0.39 | 4.65 ± 0.51 | 5.54 ± 0.53 | 4.59 ± 0.16 | 5.05 ± 0.58 |
V1/2 inactivation (mV) | −59.7 ± 1.71 | −62.3 ± 2.1 | −58.1 ± 0.83 | −62.5 ± 1.6 | −61.3 ± 1.2 | −60.6 ± 0.1 | −60.6 ± 0.96 | −60.7 ± 1.1 |
k inactivation (mV) | 6.13 ± 0.26 | 5.72 ± 0.01 | 5.57 ± 0.05 | 6.12 ± 0.17 | 5.65 ± 0.21 | 5.62 ± 0.81 | 6.03 ± 0.22 | 6 ± 0.05 |
Irsg rise (ms) | 7.36 ± 0.55 | 6.07 ± 0.22 | 6.25 ± 1.36 | 6.29 ± 0.43 | 5.08 ± 0.37 | 6.67 ± 1.58 | 5.99 ± 0.43 | 8.09 ± 0.96 |
Irsg decay τ (ms) | 27.3 ± 2.1 | 26.5 ± 3.9 | 25.8 ± 0.95 | 27.6 ± 0.99 | 22.9 ± 0.53 | 23.4 ± 0.88 | 26.1 ± 3.6 | 28.5 ± 2 |
Relative rsg (%) | 2.67 ± 0.28 | 2.3 ± 0.06 | 2.88 ± 0.39 | 2.28 ± 0.49 | 2.3 ± 0.19 | 2.69 ± 0.08 | 2.58 ± 0.26 | 2.7 ± 0.13 |