Table 5. Figure 6 electrophysiological measurements segregated by sex.
| Measure | WT | NaVβ4−/− | FGF14−/− | Double KO | ||||
|---|---|---|---|---|---|---|---|---|
| M (n = 2) | F (n = 7) | M (n = 5) | F (n = 4) | M (n = 6) | F (n = 3) | M (n = 4) | F (n = 4) | |
| Itrans eliminated by TTX (%) | 54 ± 0.51 | 44.9 ± 4.6 | 45.6 ± 3.7 | 42 ± 3.8 | 43.6 ± 3.6 | 51.3 ± 2.2 | 58.3 ± 5.1 | 42.1 ± 1.5 |
| Itransdecay τfast (ms) control | 0.62 ± 0.04 | 0.58 ± 0.02 | 0.58 ± 0.02 | 0.63 ± 0.03 | 0.53 ± 0.02 | 0.50 ± 0.04 | 0.54 ± 0.02 | 0.53 ± 0.02 |
| Itransdecay τfast (ms) TTX | 0.88 ± 0.06 | 0.67 ± 0.03 | 0.73 ± 0.05 | 0.77 ± 0.03 | 0.57 ± 0.02 | 0.70 ± 0.13 | 0.75 ± 0.11 | 0.61 ± 0.05 |
| Itransdecay τslow (ms) control | 12.8 ± 2.2 | 17.8 ± 1.1 | 18.9 ± 1.2 | 20 ± 2.6 | 15.8 ± 1.4 | 13.1 ± 0.4 | 15.4 ± 1.1 | 12.7 ± 2 |
| Itransdecay τslow (ms) TTX | 10.9 ± 3 | 13.4 ± 0.66 | 14.4 ± 0.96 | 15.2 ± 1.9 | 12.6 ± 1.7 | 8.45 ± 0.62 | 10.8 ± 1.5 | 9.94 ± 1.7 |
| Fast control (%) | 94 ± 0.1 | 93.3 ± 0.66 | 94.5 ± 0.31 | 94.5 ± 0.38 | 95.4 ± 0.47 | 94.2 ± 0.7 | 94.8 ± 0.93 | 95.1 ± 0.47 |
| Fast TTX (%) | 91.8 ± 0.65 | 94.7 ± 0.68 | 94.2 ± 1.2 | 95.2 ± 0.83 | 96.3 ± 0.64 | 93.3 ± 1.3 | 92.9 ± 1.8 | 96.4 ± 1.3 |
| Relative Irsg (%) Control | 3.78 ± 1.2 | 6.76 ± 0.98 | 5.43 ± 0.48 | 5.57 ± 0.95 | 3.87 ± 0.51 | 4.6 ± 0.7 | 4.44 ± 0.96 | 3.77 ± 0.65 |
| Relative Irsg (%) TTX | 3.08 ± 1.1 | 3.33 ± 0.16 | 3.53 ± 0.2 | 2.93 ± 0.36 | 2.28 ± 0.16 | 2.14 ± 0.24 | 2.63 ± 0.45 | 2.23 ± 0.19 |
| Proportion Irsg eliminated by TTX | 0.63 ± 0.01 | 0.71 ± 0.03 | 0.64 ± 0.02 | 0.68 ± 0.04 | 0.66 ± 0.03 | 0.77 ± 0.03 | 0.75 ± 0.02 | 0.64 ± 0.04 |
| CV control | 0.43 | 0.38 | 0.20 | 0.34 | 0.32 | 0.26 | 0.43 | 0.35 |
| CV TTX | 0.49 | 0.13 | 0.13 | 0.25 | 0.17 | 0.19 | 0.34 | 0.17 |