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Schematic diagram depicting the MAPK/ELK1 signaling pathway linking Ang II-RBM20-titin splicing. Ang II activates and phosphorylates three signal molecules, JNK, ERK1/2, and p38 in the MAPK signaling pathway, and then activates the expression of ELK1. ELK1 regulates the transcriptional and mRNA expression of RBM20, which regulates pre-mRNA splicing of titin. AR, Angiotensin II receptor.
