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. 2019 Oct 11;8(10):1234. doi: 10.3390/cells8101234

Figure 3.

Figure 3

Low frequency of intrarenal IL-2 producing effector/memory T cells in active lupus nephritis. Sorted CD4+ T cells from single spleens and kidneys of individual mice at the indicated disease stage were stimulated with PMA/ionomycin for 5 h and the frequencies of IFN-γ (A) and IL-2 (B) producing cells among CD3+CD4+CD44hi memory T cells were determined by flow cytometry (onset: n = 8 and nephritic: n = 6). Horizontal lines represent the median. Mann-Whitney U test was used for statistical analyses (* p < 0.05 and ** p < 0.01).