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. 2019 Oct 11;8(10):1235. doi: 10.3390/cells8101235
HCC: hepatocellular carcinoma
TGF-β: Transforming growth factor beta
BMP: bone morphogenetic protein
GDF: growth and differentiation factor
R-Smad: receptor-regulated Smad protein
Co-Smad: common Smad
I-Smad: inhibitory Smad
pSmad3L: the linker-phosphorylated form of Smad3
pSmad3C: the C-terminus-phosphorylated form of Smad3
MAPK: mitogen-activated protein kinase
ERK: extracellular signal-regulated kinase
PTM: post-translational modification
HBx: hepatitis B virus X protein
HCV NS3: HCV nonstructural protein 3
MMP: matrix metalloproteinase
MEF2: myocyte enhancer factors 2
Egr1: Early growth response factor 1
HSPG: heparan sulfate proteoglycan
HSC: hepatic stellate cell
IQGAP: IQ motif-containing GTPase activating protein
XIST: X-inactive specific transcript
FHL: four-and-a-half LIM protein
NEK6: NIMA-related kinases 6
NCX1: Na+/Ca2+ exchanger 1
TRPC6: transient receptor potential channel 6
SRF: serum response factor
cPLA2α: cytosolic phospholipase A2α