Figure 1.
Characteristics of TGN tethering factors. (A) Schematic representation of golgin coiled-coil tethers associated with the TGN (Golgin-245, Golgin-97, GCC88, and GCC185) and the late Golgi apparatus (TMF1). The location of a GRIP domain near the C terminus (black segment), a RAB6-binding region (RBD; light gray segment), and the total number of amino acids in each human protein are indicated. For additional details, see Cheung and Pfeffer (2016). (B) Schematic representation of GARP and EARP MTCs. GARP is composed of VPS51, VPS52, VPS53, and VPS54, whereas EARP is composed of VPS50, VPS51, VPS52, and VPS53. Amino acid numbers in the human proteins are indicated. For additional details, see Schindler et al. (2015).