Table 2.

Insulin content of isolated human islets.

A Values unrelated to islet size
Ref	First Author	Year	Donors (n)	Islets/Sample	Insulin (ng/islet)	CV (%)	Isolation center
[49]	Sandler	1997	8	30	∼19	∼35	Brussels (VUB)
[50]	Conget	1997	7	10	32.4	19	Barcelona
[51]	Straub	1998	12	5	44	63	Leicester
[52]	Hadjivasiliou	1998	8	5	16.2	23	Leicester
[53]	Bjorklund	2000	12	3–5	13.9	105	Brussels (VUB)
[54]	Marchetti	2004	10	30	4.0	27	Pisa
[55]	Henquin	2015	22	>300	17.8	45	Brussels (UCL), Lille
[56]	Manning Fox	2015	56	20	24.3	71	Edmonton
[57]	Brandhorst	2017	34	?	10.3	124	Geneva, Uppsala, Oxford
[58]	Li	2017	12	?	∼60	∼35	Several Centers USA
[59]	Thomsen	2018	16	15	∼46	∼55	Oxford, Edmonton
[60]	Lorza-Gil	2019	13	5	∼21	∼65	Geneva, Lille, Milan
			210
Mean					25.7 (CV65%)	56%
Weighted mean excluding 2 most outliers					22.8
Median					20.0

B Values normalized to IEQ
Ref	First Author	Year	Donors (n)	Islets/sample	Insulin (ng/IEQ)	CV (%)	Isolation center
[61]	Jahr	1983	7	5b	∼17a	∼20	Karlsburg-Greifswald
[62]	Brandhorst	2003	54	?	5.0	115	Giessen
[63]	Nano	2005	12	1000	6.5	–	Milan
[64]	Guthalu	2010	5	15	∼14.5	∼35	Several centers USA
[65]	Dai	2012	5	?	∼16	∼25	Several centers USA
[66]	Lefebvre	2012	6	40	∼12.5	∼40	Lille
[67]	Zuellig	2017	4	?	∼23a	–	Geneva, Milan, Giessen
[68]	Qi	2018	10	400	∼10	∼65	Duarte
[69]	Henquin	2018	43	>300	18.4	43	Brussels (UCL), Lille
[70]	Haliyur	2019	6	?	∼10	∼75	Pittsburg
			152
Mean					13.3 (CV42%)	52%
Weighted mean excluding 2 most outliers					14.6
Median					13.5

Original data in pmol/islet or μUnits/islet were converted into ng/islet (1 pmol Insulin = 5.8 ng) (1 μU Insulin = 34.7 pg).

The sign ∼ indicates that the value was read from a Figure in the original publication.

?: Unknown number of islets per sample.

^aValue obtained after recalculation of published data.

^bFresh islets.