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. 2019 Oct 20;8(10):1285. doi: 10.3390/cells8101285

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the fission yeast nucleus. Schematic representation of a fission yeast cell (above). Magnification of the area marked by dashed lines (below). Global chromosome organization with centromeres attached underneath the spindle pole body (SPB) and telomeres and nucleolus distantly positioned. Chromatin is linked to the nuclear envelope (NE) by the interaction of different genomic elements with inner nuclear membrane (INM) proteins and linker of nucleoskeleton and cytoskeleton (LINC) complexes. Note that the interaction of Lem2 protein with chromatin might be indirect. The NE is continuous with the perinuclear endoplasmic reticulum. The SBP and other microtubule organizing centers (MTOCs) organize antiparallel bundles of microtubules (MTs).