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. 2019 Nov 4;20:243. doi: 10.1186/s12931-019-1215-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The mRNA level of the aging-associated genes FOXO3, TP53, TGFβ1, MMP2, HDAC1, NUF2, ATG3, and AREG were significantly down-regulated in peripheral blood of COPD patients. (a-h) The mRNA expression of these genes was detected by qPCR. *** p < 0.001; **** p < 0.0001