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. 2019 Nov 4;38:450. doi: 10.1186/s13046-019-1440-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Expression of PHB1 and PHB2 in DLBCL cell lines, normal B cells and patient samples. a Expression of PHBs were analyzed by Western blotting in cell lysates of GCB (SUDHL4, SUDHL6) and ABC (OCI-LY3, OCI-LY10) DLBCL cell lines, as compared to peripheral normal B lymphocytes isolated from PBMCs of 4 healthy donors (of whom NB1 and NB2 were female and NB3 and NB4 were male donors). Actin was used as a loading control. The Western blots have been quantified by densitometry and normalized to actin intensity. The quantitative values have been incorporated below the Western blots bands. b Examples of immunohistochemical stainings of PHB1, PHB2, and AIF in DLBCL tumor samples (× 200) and normal reactive lymph nodes (RLN, × 200, n = 3). c Box-plot analysis showing the distribution of total immunostaining scores determined for the tumor samples (n = 82). The horizontal line corresponds to the median value and the box length to the interquartile range. Box whiskers represent the maximum and minimum range excluding extreme outliers (shown as dots). Kaplan-Meier plots of OS (d) and EFS (e) in patients with DLBCL (n = 82) stratified by PHB1 expression level, as indicated in the Methods section. Kaplan-Meier plots of EFS in f male (n = 48) and g female patients (n = 34)