Fig. 7.

FL3 inhibits the growth of DLBCL tumors xenografted in mice. SCID mice bearing tumors from SUDHL4 cells were injected i.p. with either vehicle or FL3 (15 mg/kg) twice per week for 2 weeks. a The means ± SEM of tumor volume from the mice are shown. b Tumors were immunostained for Ki67 and AIF. IHC photographs are representative fields from control and FL3 treated animals. Images of IHC staining of Ki67 was quantified using ImageJ software and data are expressed as means ± SD of 3 independent fields of each tumor sample for the 2 control and the 2 FL3 treated mice. c Western blotting was performed to detect the protein expression levels of the indicated molecules from tumor samples. Actin or GAPDH was used as a loading controls. Representative data of two independent experiments are shown for vehicle control- and FL3-treated mice