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Schematic representation of the potential pathway for SHP2 de-phosphorylation of receptor tyrosine kinases (RTKs) and cytokine receptors (CR) in oocytes and blastocysts. Upon ligand binding these receptors are hyper-phosphorylated and SHP2 de-phosphorylate them by taking phosphate group, as a result the adaptor proteins get attached to the receptors and signal transduction starts.
