Figure 8.

Diagrammatic sketch of this study. PLIN5 was up-regulated by cellular stress induced by H₂O₂ or LPS treatment. Then, the increased PLIN5 levels promoted cellular LD formation and expansion, expression levels of COXs and LDs contacting with mitochondria. Subsequently, LD formation and expansion reduced the levels of cellular fatty acids, which promoted the alleviation of stress. COXs’ up-regulation reduced the release of cytochrome c from mitochondria to cytoplasm and reduced the mitochondrial damage. The contacts between LDs and mitochondria helped the transfer of potential harmful proteins from mitochondria to LDs. Therefore, cellular stress was alleviated.