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. 2019 Jun 5;16:100107. doi: 10.1016/j.jctube.2019.100107

Table 3.

Diagnostic value of different indexes as predictors of pulmonary TB (positive Xpert test).

Xpert-positive Xpert-negative P valuea Sensitivity Specificity PPV NPV
WHO4SS: at least one symptom 18/21, 85.7% 42/122, 34.4% <0.001 85.7b,d 65.6d,f 30.0 96.4
Neopterin, >10 nmol/L 20/21, 95.2% 89/122, 73.0% 0.027 95.2c,d 27.0f,g 18.3 97.1
CRP, >10 mg/L, 16/21, 76.2% 6/122, 4.9% <0.001 76.2b,c 95.1e,g 72.7 95.9
a

Chi-square test or Fisher test

PPV: positive predictive value; NPV: negative predictive value.

b

WHO-4SS versus CRP >10 mg/L: p value for the comparison of sensitivity: 0.688, McNemar test.

c

CRP>10 mg/L versus Neopterin >10 nmol/L: p value for the comparison of sensitivity: 0.127, McNemar test.

d

WHO-4SS versus neopterin >10 nmol/L: p value for the comparison of sensitivity: 0.625, McNemar test.

e

WHO-4SS versus CRP >10 mg/L: p value for the comparison of specificity: <0.001, McNemar test.

f

WHO-4SS versus neopterin >10 nmol/L: p value for the comparison of specificity: <0.001, McNemar test.

g

CRP>10 mg/L versus Neopterin >10 nmol/L: p value for the comparison of specificity: <0.001, McNemar test.