Table 2. Predictors of use of pharmacological treatment for osteoporosis (comparator is all others who are not given any pharmacological therapy for osteoporosis, i.e. entire cohort from FY2005 – FY2015).
| Predictors | Univariate | Multivariate | ||
|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | |
| Demographics | ||||
| Age (> 50 vs. ≤ 50) | 1.25 | 1.10−1.43 | 1.6 | 1.31−1.94 |
| Race | ||||
| (Black vs. White) | 0.47 | 0.39−0.58 | 0.43 | 0.33−0.57 |
| (Asian vs. White) | 0.76 | 0.33−1.76 | 0.85 | 0.28−2.57 |
| (American Indian/Alaskan vs. White) | 0.78 | 0.40−1.49 | 0.64 | 0.24−1.69 |
| (Hawaiian/Pacific Islander vs. White) | 1.27 | 0.74−2.15 | 1.14 | 0.52−2.51 |
| Ethnicity (Hispanic vs. Non-Hispanic) | 0.89 | 0.66−1.21 | 0.75 | 0.49−1.15 |
| Sex (Female vs. Male) | 3.39 | 2.59−4.44 | 4.09 | 2.74−6.09 |
| Clinical Factors | ||||
| BMI (Underweight vs Normal) | 1.04 | 0.79−1.36 | 1.14 | 0.78−1.66 |
| BMI (Overweight vs Normal) | 0.87 | 0.75−1.00 | 0.84 | 0.67−1.04 |
| BMI (Obese vs Normal) | 0.59 | 0.49−0.71 | 0.59 | 0.45−0.76 |
| Opioid 1 Year Prior to Index* Date (Yes vs. No) | 1.93 | 1.69−2.19 | 1.24 | 1.01−1.51 |
| Corticosteroids 1 Year Prior to Index* Date (Yes vs. No) | 3.54 | 2.80−4.48 | 1.92 | 1.27−2.92 |
| Anticonvulsants 1 Year Prior to Index* Date (Yes vs. No) | 1.56 | 1.36−1.79 | 1.14 | 0.92−1.41 |
| SCI-Related Factors | ||||
| SCI Level (Paraplegia vs. Tetraplegia) | 1.27 | 1.10−1.45 | 1.1 | 0.91−1.34 |
| SCI Extent (Complete vs. Incomplete) | 1.43 | 1.24−1.66 | 1.26 | 1.04−1.53 |
| DXA 1 Year Prior to Index Date* (Yes vs. No) | 87.62 | 66.09−116.17 | 84.03 | 59.80−118.07 |
| Lower Extremity or Pathological Fracture 1 Year Prior to Index Date* (Yes vs. No) | 7.02 | 5.82−8.46 | 5.43 | 4.13−7.15 |
CI, confidence interval; OR, odds ratio.
*Index date for those with a filled prescription was the date of their first filled prescription.
Index date for those without a filled script was the date of their first utilization plus 905 days.