Table 1.
Blood and urine tests evaluation of nephrectomy and ischemia/reperfusion groups.
| Sham + placebo | Sham + anti-C5 (p value compared with sham + placebo) | I/R + placebo (p value compared with sham + placebo) | I/R + low dose (p value compared with I/R + placebo) | I/R + high dose (p value compared with I/R + placebo) | |
|---|---|---|---|---|---|
| Blood tests | |||||
| Hemoglobin (g/dL) | 13.2 ± 0.8 | 12.8 ± 0.4 (p=.48) |
11.8 ± 1.3 (p=.08) |
12.2 ± 1 (p=.29) |
11.7 ± 0.9 (p=.89) |
| White blood cells (K/uL) | 4.5 ± 2.9 | 5.5 ± 3.3 (p=.28) |
4.4 ± 3.1 (p=.92) |
6 ± 3.3 (p=.46) |
3.8 ± 3.6 (p=.65) |
| Platelets (K/uL) | 698 ± 213 | 650 ± 299 (p=.78) |
740 ± 225 (p=.6) |
765 ± 93 (p=.82) |
884 ± 171 (p=.016) |
| Renal function tests and histopathology | |||||
| Cystatin C (mg/L) | 0.98 ± 0.34 | 0.77 ± 0.84 (p=.62) |
1.63 ± 0.62 (p=.04) |
1.36 ± 0.71 (p=.08) |
1.21 ± 0.46 (p= .03) |
| Acute tubular necrosis (%) | 0 ± 0 | 0 ± 0 (p>.99) |
37.5 ± 34.5 (p= .045) |
18.8 ± 12.5 (p=.26) |
25 ± 20.4 (p=.43) |
| Nucleus degeneration (%) | 0 ± 0 | 0 ± 0 (p>.99) |
25 ± 5 (p= .01) |
25 ± 28.9 (p>.99) |
17.9 ± 18.9 (p=.38) |
| Proliferation (%) | 0 ± 0 | 0 ± 0 (p>.99) |
33.3 ± 20.4 (p=.01) |
31.3 ± 23.9 (p=.89) |
35.7 ± 34.9 (p=.89) |
| Protein casts- cortex (%) | 0 ± 0 | 0 ± 0 (p>.99) |
8.3 ± 12.9 (p=.18) |
6.3 ± 12.5 (p=.81) |
10.7 ± 19.7 (p=.81) |
| Protein casts- medulla (%) | 0 ± 0 | 0 ± 0 (p>.99) |
25 ± 22.4 (p=.04) |
18.8 ± 23.9 (p=.68) |
32.1 ± 31.3 (p=.65) |
| Immunofluorescence | |||||
| C3 (intensity* 109) | 0.6 ± 0.27 | 0.52 ± 0.25 (p=.67) |
3.03 ± 0.57 (p<.001) |
1.46 ± 0.57 (p=.002) |
2.31 ± 0.28 (p=.05) |
| C6 (intensity* 109) | 1.03 ± 0.48 | 1.36 ± 0.03 (p=.16) |
2.68 ± 0.52 (p<.001) |
1.4 ± 0.11 (p=.002) |
1.45 ± 0.52 (p=.003) |
| Systemic inflammatory tests (serum) | |||||
| CRP (mg/L) | 0.33 ± 0.06 | 0.3 ± 0.01 (p=.19) |
0.47 ± 0.21 (p=.05) |
0.36 ± 0.1 (p=.013) |
0.33 ± 0.06 (p=.01) |
| IL-1 (pg/mL) | 109 ± 3 | 129 ± 35 (p=.57) |
117 ± 6 (p=.21) |
128 ± 50 (p=.48) |
114 ± 6 (p=.33) |
| IL-6 (pg/mL) | 102 ± 29 | 119 ± 48 (p=.58) |
87 ± 4 (p = 58) |
94 ± 13 (p=.07) |
88 ± 7 (p=.72) |
| C3 (µcg/L) | 68.8 ± 24.8 | (N/A) | 45.5 ± 47.1 (p=.44) |
3.3 ± 1.9 (p=.03) |
22.0 ± 9.3 (p=.36) |
| C4 (ng/L) | 287 ± 76 | (N/A) | 371 ± 86 (p=.16) |
468 ± 108 (p=.1) |
383 ± 125 (p=.85) |
| Classical (%) | 76 ± 5 | (N/A) | 73 ± 12 (p=.61) |
81 ± 9 (p=.17) |
72 ± 13 (p=.86) |
| Alternative (%) | 85 ± 9 | (N/A) | 79 ± 25 (p=.57) |
84 ± 14 (p=.67) |
81 ± 9 (p=.88) |
Data are presented as mean ± SD.
p-value <.05 is highlighted in bold.
I/R: ischemia reperfusion; CRP: C-reactive protein; IL: interleukin.