. 2019 Oct 24;6(Pt 6):1106–1119. doi: 10.1107/S2052252519013137

Table 2. β₂AR ligands used in the exchange experiments with their MoAs, molecular weights (MW) and affinity (K _i) values.

Data are from the ChEMBL database (ChEMBL_23; Gaulton et al., 2012 ▸). Chemical structures of the ligands used for the other receptors in this study are shown in Supplementary Fig. S4.

Ligand	MoA	ChEMBL ID	MW (Da)	K _i (nM)	Reference
ICI-118,551	Inverse agonist	CHEMBL513389	277.4	0.13	Dolušić et al. (2011 ▸)
Carazolol	Inverse agonist	CHEMBL324665	298.4	0.114	Sabio et al. (2008 ▸)
Timolol	Inverse agonist	CHEMBL499	316.4	0.201^†
Propranolol	Inverse agonist	CHEMBL27	259.3	3.69	Plazinska et al. (2014 ▸)
Alprenolol	Antagonist	CHEMBL266195	249.4	1	Aristotelous et al. (2013 ▸)
Carvedilol	β-Arrestin-biased agonist	CHEMBL723	406.5	0.166^†
Procaterol	Agonist	CHEMBL160519	290.4	78	Baker (2010 ▸)
Formoterol	Agonist	CHEMBL3989798	344.4	23	Baker (2010 ▸)

^†

Values are from the DrugMatrix Database (https://ntp.niehs.nih.gov/drugmatrix/index.html).

Table 2. β2AR ligands used in the exchange experiments with their MoAs, molecular weights (MW) and affinity (K i) values.

Table 2. β₂AR ligands used in the exchange experiments with their MoAs, molecular weights (MW) and affinity (K _i) values.