Table 2. Differential diagnosis of epithelioid hemangioma of spine.

	Age Sex	Location	CT images features	MRI features	Key facts
Aneurysmal bone cyst12,13	< 30 y F > M	Lumbar spine Posterior element or pedicle	Osteolytic lesion, cortical eggshell	Heterogeneous lesions Hypointense and hyperintence on T1 – and T2WI	Local curettage is the treatment option, Local recurrence may occur
Giant cell tumor14–16	20–40 y F>M	Sacrum Vertebral body	“Soap bubble” expansive osteolytic lesion	Hypointense on T2WI.	Aggressive resection is needed. Local recurrence and sometime metastasize
Chondrosarcoma17,18	50–60 y M >F	Thoracic spine	Expansive osteolytic lesions with diffuse, mottled “ring and arc ” calcification	Hypointense and hyperintence on T1 – and T2WI	Complete en-bloc surgical resection is needed.
Hemangioma19,20	Incidence increases with age F > M	Vertebral body > posterior element	“Honeycomb“ appearance and “polka dot” appearance on axial CT	Hyperintense signal on both T1- and T2WI	In aggressive type, tumor may extend epidurally and cause cord compression
Epithelioid hemangioma4,6–11,21	20–65 years M > F	Thoracic spine Transverse process	Multilocular and expanding lytic lesion	Isointence on T1WI, hyperintence on T2WI	Local recurrence and may occur.