. Author manuscript; available in PMC: 2019 Nov 5.

Published in final edited form as: Biol Psychiatry. 2019 Jan 17;85(10):850–862. doi: 10.1016/j.biopsych.2018.12.022

Table 3.

Effects of MDDSuicide, Early Life Adversity, and Dentate Gyrus Region (Anterior, Mid, or Posterior) on Dentate Gyrus Cells and Volume

	B	SE	df	t Value	p Value
(log) Granule Neuron Number ~ ELA + MDDSuicide + Region + MDDSuicide × Region
MDDSuicide	−0.64	0.14	49	−4.67	< .0001^a
ELA	0.39	0.10	49	3.86	.0003^a
Region (MidDG vs. AntDG)	−0.25	0.12	93	−2.13	.0362
Region (PostDG vs. AntDG)	−0.85	0.12	93	−6.97	< .001^a
Region (MidDG vs. AntDG) × MDDSuicide^b	0.04	0.16	93	0.24	.8072
Region (PostDG vs. AntDG) × MDDSuicide^b	0.67	0.17	93	3.90	.0002^a
(log) Glia Number ~ ELA + MDDSuicide + Region
MDDSuicide	0.06	0.08	49	0.81	.4225
ELA	0.19	0.08	49	2.49	.0160
Region (MidDG vs. AntDG)	−0.16	0.09	88	−1.76	.0825
Region (PostDG vs. AntDG)	−0.45	0.09	88	−4.91	< .0001^a
(log) Neural Progenitor Cell Number ~ ELA + MDDSuicide + Region + ELA × MDDSuicide + MDDSuicide × Region
MDDSuicide	−3.06	0.30	48	−10.13	< .0001^a
ELA	−0.60	0.25	48	−2.43	.0190
Region (MidDG vs. AntDG)	−0.22	0.22	93	−1.01	.3148
Region (PostDG vs. AntDG)	−0.48	0.23	93	−2.08	.0399
Region (MidDG vs. AntDG) × MDDSuicide^b	1.20	0.31	93	3.87	.0002^a
Region (PostDG vs. AntDG) × MDDSuicide^b	1.56	0.32	93	4.81	< .0001^a
MDDSuicide × ELA	1.00	0.35	48	2.88	.0059^a
Dentate Gyrus Volume ~ ELA + MDDSuicide + Region + ELA × MDDSuicide
MDDSuicide	−10.51	2.82	48	−3.73	.0005^a
ELA	18.76	2.82	48	6.66	< .0001^a
Region (MidDG vs. AntDG)	−7.18	2.42	98	−2.96	.0039^a
Region (PostDG vs. AntDG)	−4.11	2.47	98	−1.66	.0999
MDDSuicide × ELA^c	−21.09	4.01	48	−5.26	< .0001^a

AntDG, anterior dentate gyrus; ELA, early life adversity; MDD, major depressive disorder; MDDSuicide, subjects with MDD who died by suicide; MidDG, mid dentate gyrus; PostDG, posterior dentate gyrus.

These p values are significant at the α = .0125 level (i.e., adjusted for the four outcomes using the Bonferroni method).

When an interaction between MDDSuicide and Region is included in the model, the main effect of MDDSuicide denotes the test of difference between suicides and control subjects in the AntDG, while the interaction terms test the difference in MDDSuicide effect between MidDG or PostDG and AntDG.

When an interaction between MDDSuicide and ELA is included in the model, the main effect of ELA tests the difference between control subjects with and without ELA, the main effect of MDDSuicide tests the difference between suicide decedents with MDD without ELA and control subjects without ELA, while the interaction term tests the difference in the ELA effect between suicide decedents with MDD and control subjects.