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. 2019 Oct 6;8(10):1208. doi: 10.3390/cells8101208

Figure 1.

Figure 1

(A) Schematic of generating CDK8/19 single- and double-knockout derivatives of 293 cells. (B) Western blot analysis of CDK8 and CDK19 expression in 293 cells and their knockout derivatives in the absence or presence of senexin B (3 h treatment). (C) Effects of TNFα and senexin B on the mRNA expression of CXCL1 and IL8 in 293 cells and their knockout derivatives (QPCR). Data are presented as mean ± SEM (n = 3). Asterisks: p < 0.01 (t-test) for the differences between TNFα and TNFα + senexin B readouts.