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(A) Chemical structures of thienopyridine derivatives 15k, 15n, 15q, 15u, 15v and 15w. (B) Comparisons of IC50 values of the indicated thienopyridines measured in the NFκB reporter assay in WT 293 cells with the reported EC200 values in the ALPase activity assay in ST2 cells. (C) Effects of 15k, 15u and 15w at different concentrations on the induced NFκB reporter activity in WT and dKO 293 cells treated with 10 ng/mL TNFα for 3 h.
