Table 3.
Univariate And Multivariate Analysis Of Prognostics Factors Affecting OS For Two Treatment Cohorts
| Variables | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| Numbers | HR | P value | HR | P value | ||
| Sex (Male vs Female) | 114/11 | 0.645(0.322–1.293) | 0.217 | – | – | |
| Age (≥56 vs <56) | 64/61 | 0.759(0.491–1.173) | 0.214 | – | – | |
| AFP level (≥400 ng/mL vs <400 ng/mL) | 65/60 | 1.644(1.050–2.572) | 0.030 | – | – | |
| HBV (Present vs Absent) | 112/13 | 1.231(0.592–2.561) | 0.578 | – | – | |
| Child Pugh Class (B vs A) | 14/111 | 0.805(0.398–1.626) | 0.545 | – | – | |
| Tumor size (≥5 cm vs <5 cm) | 75/50 | 1.794(1.135–2.837) | 0.012 | 1.732(1.086–2.760) | 0.021 | |
| Number of lesions (Multiple vs Single) | 108/17 | 1.676(0.807–3.481) | 0.166 | – | – | |
| PVTT (Present vs Absent) | 40/85 | 1.591(1.001–2.528) | 0.050 | 2.297(1.379–3.827) | 0.001 | |
| Distant metastasis (Present vs Absent) | 71/54 | 1.580(1.005–2.485) | 0.048 | 1.962(1.223–3.148) | 0.005 | |
| Number of Previous TACE (>2 VS ≤2) | 29/96 | 0.709(0.413–1.214) | 0.210 | – | – | |
| Treatments (TACE-apatinib vs TACE) | 42/83 | 0.459(0.274–0.770) | 0.003 | 0.280(0.158–0.499) | <0.001 | |
Notes: Tumor size, PVTT, distant metastasis and treatments in this study were independent prognostic factors of OS.
Abbreviations: OS, overall survival; AFP, alpha-fetoprotein; HBV, Hepatitis B Virus; PVTT, portal vein tumor thrombus; BCLC, Barcelona Clinic Liver Cancer; TACE, transcatheter arterial chemoembolization.