Table 1.

Demographic And Disease Characteristics Of Studies Of Depression And Anxiety In Youth With JIA (2009–2019)

Author (Year)	Country	Study Design	Sample Size		Female %	Mean Age Years (SD)*	Disease Duration (Months)	Percentage By JIA Subtype %
Subjects	Control	Oligo-Articular	Poly-Articular	RF –Poly	RF +Poly	ERA	PSA	Systemic	Undifferentiated
Banasiak et al (2010)50	Poland	Cross-Sectional	30	0	63	15.4	NS	NS	NS	NS	NS	NS	NS	NS	NS
Reda et al (2011)30	Egypt	Cross-Sectional	30	30	53	8-16	6−144	7	76	53	23	NS	NS	17	0
Tarakci et al (2011)31	Turkey	Cross-Sectional	52	51	63	12.1 (2.9)	5–180	28	52	35	17	8	6	4	2
Vuorimaa et al (2011)24	Finland	Cross-Sectional	142a	0	73	11.9 (3)	12–168	50	50	NS	NS	NS	NS	NS	NS
Anthony et al (2011)25	USA	Cross-Sectional	51a	0	61	12.4 (2.8)	3–144	0	63	NS	NS	8	6	23	NS
Lal et al (2011)26	UK	Longitudinal	204a	0	62	13.4	4–27	46	23	18	5	13	7	6	5
Barsdorf (2011)27	USA	Cross-Sectional	36	0	75	15.5	12–180	NS	NS	NS	NS	NS	NS	NS	NS
Russo et al (2012)32	Italy	Cross-Sectional	33	0	70	10.5 (4)	At least 6	NS	NS	NS	NS	NS	NS	NS	NS
Hrelic et al (2013)28	USA	Cross -Sectional	49a	0	71	13	NA	NA	NA	NA	NA	NA	NA	NA	NA
Bromberg et al (2012)45	USA	Longitudinal	51	0	65	12.4	At least 1.5	0	100	NS	NS	0	0	0	0
Castaneda et al (2013)33	Finland	Cross -Sectional	34b	23f	61	15.5 (1.2)	<12: 9% 12–24: 4% >24 87%	NS	NS	NS	NS	NS	NS	NS	NS
Stevanovic et al (2013)34	Serbia	Cross -Sectional	67a	0	71	13.6	6–168	NS	NS	NS	NS	NS	NS	NS	NS
Bomba et al (2013)35	Italy	Cross -Sectional	39	80	69	11.4 (2.1)	5–70.24	62	28	NS	NS	3	3	4	0
Mulligan et al (2013)36	UK	Cross -Sectional	171c	0	72	9 (4.1)	8.4–87.6	32	43	37	5	6	4	15	0
El-Naijar et al (2014)37	Egypt	Cross-Sectional	54	0	67	11 (2.7)	12–120	39	28	NS	NS	11	0	22	0
Abdul-Sattar, Magd et al (2014)38	Egypt	Cross-Sectional	52	0	67	9.5	12–132	46	31	NS	NS	0	0	23	0
Abdul-Sattar, Elewa et al (2014)39	Egypt	Cross-Sectional	58	0	71	7-17	12–120	48	30	9	21	0	0	22	0
Haverman et al (2014)40	Netherlands	Cross-Sectional	155c	0	67	11.5 (4.6)	2–168	36	42	39	3	11	0	4	5
Kuburovic et al (2014)47	Serbia	Cross-Sectional	25d	50 JIA 89 Healthy	52	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
Memari et al (2016)41	Iran	Cross-Sectional	51	75	55	11.2 (3.5)	27.6–70.6	NS	NS	NS	NS	NS	NS	NS	NS
Graziano et al (2016)48	Italy	Cross-Sectional	15e	15f	60	6.6 (3.2)	NS	NS	NS	NS	NS	NS	NS	NS	NS
Hanns et al (2018)46	UK	Longitudinal	102	0	57	13.2	NS	52	30	NS	NS	18	NS	NS	NS
Butler et al (2018)29	Canada	Longitudinal	28% asthma 18% diabetes 16% epilepsy 16% food allergy 22% JIA	0	48	11.3	NS	NS	NS	NS	NS	NS	NS	NS	NS
Kayan Okacoglu et al (2018)23	Turkey	Cross-Sectional	48 PID 32 JIA	30	28	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
Korte-Bouws et al (2019)53	Netherlands	Cross-Sectional	24	0	63	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS

Notes: ^aProxy also included as part of the study. ^bStudy population was inflammatory bowel disease. ^cStudy population was the legal guardian. ^dStudy population was patients with primary immunodeficiencies. ^eStudy population was patients with malignant solid tumors. ^fControl population was juvenile idiopathic arthritis. *When mean age was not provided, reported age range for the study is given.

Abbreviations: JIA, juvenile idiopathic arthritis; PID, primary immunodeficiency; NS, not stated; NA, not applicable.