Table 2. Genotype frequencies of MMP1 and MMP3 gene polymorphisms in cases and controls.
| Models | Genotype | Case (n, %) | Control (n, %) | OR (95% CI) | P-value | *OR (95% CI) | *P-value |
|---|---|---|---|---|---|---|---|
| rs1799750 | |||||||
| Co-dominant | 1G/1G | 37 (24.8%) | 50 (33.8%) | 1.00 (reference) | - | 1.00 (reference) | - |
| Heterozygote | 1G/2G | 74 (49.7%) | 73 (49.3%) | 1.37 (0.80–2.34) | 0.248 | 1.33 (0.78–2.28) | 0.295 |
| Homozygote | 2G/2G | 38 (25.5%) | 25 (16.9%) | 2.05 (1.06–3.97) | 0.033 | 2.01 (1.03-3.89) | 0.040 |
| Dominant | 1G/1G | 37 (24.8%) | 50 (33.8%) | 1.00 (reference) | - | 1.00 (reference) | - |
| 1G/2G+2G/2G | 112 (75.2%) | 98 (66.2%) | 1.54 (0.93–2.56) | 0.091 | 1.51 (0.91–2.50) | 0.114 | |
| Recessive | 1G/1G+1G/2G | 111 (74.5%) | 123 (83.1%) | 1.00 (reference) | - | 1.00 (reference) | - |
| 2G/2G | 38 (25.5%) | 25 (16.9%) | 1.68 (0.96–2.97) | 0.071 | 1.67 (0.95–2.95) | 0.076 | |
| Allele | 1G | 148 (49.7%) | 173 (58.4%) | 1.00 (reference) | - | 1.00 (reference) | - |
| 2G | 150 (50.3%) | 123 (41.6%) | 1.43 (1.03–1.97) | 0.032 | - | - | |
| rs3025058 | |||||||
| Co-dominant | 6A/6A | 96 (64.0%) | 100 (66.7%) | 1.00 (reference) | - | 1.00 (reference) | - |
| Heterozygote | 5A/6A | 48 (32.0%) | 42 (28.0%) | 1.19 (0.72–1.96) | 0.494 | 1.15(0.69–1.90) | 0.599 |
| Homozygote | 5A/5A | 6 (4.0%) | 8 (5.3%) | 0.78 (0.26–2.34) | 0.659 | 0.79 (0.26–2.36) | 0.666 |
| Dominant | 6A/6A | 96 (64.0%) | 100 (66.7%) | 1.00 (reference) | - | 1.00 (reference) | - |
| 5A/6A+5A/5A | 54 (36.0%) | 50 (33.3%) | 1.13 (0.70–1.81) | 0.628 | 1.09 (0.68–1.76) | 0.731 | |
| Recessive | 6A/6A+5A/6A | 144 (96.0%) | 142 (94.7%) | 1.00 (reference) | - | 1.00 (reference) | - |
| 5A/5A | 6 (4.0%) | 8 (5.3%) | 0.74 (0.25–2.19) | 0.585 | 0.75 (0.25–2.23) | 0.609 | |
| Allele | 6A | 240 (80.0%) | 242 (80.7%) | 1.00 (reference) | - | 1.00 (reference) | - |
| 5A | 60 (20.0%) | 58 (19.3%) | 1.04 (0.70–1.56) | 0.837 | - | - |
The genotyping was successful in 149 cases and 148 controls for rs1799750; the genotyping was successful in 150 cases and 150 controls for rs3025058. Bold values are statistically significant (P<0.05).
*
Adjusted for age and sex.