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. 2019 Nov 1;14:8603–8610. doi: 10.2147/IJN.S218988

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© 2019 Wei et al.

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Intracellular distribution of Dox (A) and Exo-DOX (B) after 1 hrs, 4 hrs and 24 hrs incubation with MG63 cells, bar was 50μm. The histogram (C) and Quantification (D) of internalized Dox, Exo-Dox using flow cytometry after incubation with MG63cells for 1 h,4 h and 24 h. All of the data are presented as mean±s.d. (n=3) and analyzed with two-way ANOVA (****P < 0.0001).