Table 1.
Example calculation of the severity-weighted cost effectiveness
| Model run (s) | Disease burden calculation | Model results | Combined results | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| QALE patients (Qd) | QALE general population with same age and gender (Qn) | Absolute shortfall (Qn − Qd) | Proportional shortfall [(Qn − Qd)/Qn)] | Applicable threshold (Vs) | Incremental costs, € (∆C) | Incremental benefits (∆Q) | ICER, € (∆C/∆Q) | INMB, € (∆Q × Vs − ∆C) | Cost-effective?a | |
| 1 | 15 | 25 | 10 | 0.40 | 20,000 | 20,000 | 0.60 | 33,333 | − 8000.00 | 0 |
| 2 | 16 | 24 | 8 | 0.33 | 20,000 | 8000 | 0.50 | 16,000 | 2000.00 | 1 |
| 3 | 17 | 28 | 11 | 0.39 | 20,000 | 15,000 | 0.60 | 25,000 | − 3000.00 | 0 |
| 4 | 15 | 28 | 13 | 0.46 | 50,000 | 10,000 | 0.50 | 20,000 | 15,000.00 | 1 |
| 5 | 14 | 27 | 13 | 0.48 | 50,000 | 10,000 | 0.40 | 25,000 | 10,000.00 | 1 |
| 6 | 13 | 26 | 13 | 0.50 | 50,000 | 25,000 | 0.30 | 83,333 | − 10,000.00 | 0 |
| 7 | 15 | 26 | 11 | 0.42 | 20,000 | 25,000 | 0.60 | 41,667 | − 13,000.00 | 0 |
| 8 | 15 | 32 | 17 | 0.53 | 50,000 | 15,000 | 0.50 | 30,000 | 10,000.00 | 1 |
| 9 | 16 | 25 | 9 | 0.36 | 20,000 | 25,000 | 0.60 | 41,667 | − 13,000.00 | 0 |
| 10 | 16 | 26 | 10 | 0.38 | 20,000 | 20,000 | 0.80 | 25,000 | − 4000.00 | 0 |
| Severity weighted probability of being cost effective | 40% | |||||||||
ICER incremental cost-effectiveness ratio, INMB incremental net monetary benefit, QALE quality-adjusted life expectancy
a1 = Yes