| Despite similar and reasonable fits to the observed Kaplan–Meier curve from the evaluated immuno-oncology (IO) trial, the long-term overall survival extrapolation differed substantially across the various survival models examined. |
| Cure, parametric mixture and landmark models may better account for the potential mechanism of action of IO treatments, whereby a plateau in long-term survival is observed. |
| A consistent and scientifically grounded approach to survival extrapolations is required to demonstrate the potential value of IO treatments. |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.