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. Author manuscript; available in PMC: 2019 Nov 5.
Published in final edited form as: Bioconjug Chem. 2018 Jul 9;29(7):2436–2447. doi: 10.1021/acs.bioconjchem.8b00335

Figure 2:

Figure 2:

(A) Timeline of the injury and treatment. (B) Blood loss over 60 minutes with saline infusions at 15, 30 and 60 minutes. The dotted lines represent the SE for each timepoint (n=4). (C) Schematic of the injury. The left lobe (LL) is isolated from the underlying anatomy and medial lobe (left LML; right RML) with a malleable retractor and measured and marked with cautery 2” from the apex (1). Two additional measurements are made from the apex to the lateral aspects of the resection line to ensure consistent equilateral angles (2 & 3). Ring clamps are used to hold the liver while the injury is made. The liver is resected to the left lobe midline (1), starting from patient---right. This is allowed to bleed for 1 minute with ring clamps still holding proximal to the injury line, and then the remaining liver is cut. After the injury is made, the left lobe is placed back in its natural resting place to prevent alteration of normal hepatic blood flow. VC=hepatic inferior vena cava. (D) Cross section of a resected section of the liver lobe showing the major vessels. (E) Quantification of vessel diameters at surface of resected liver