Table 2A.

GBE-HCC vs CNTL: Top 20 genes with concordance of hypomethylated promoter regions and upregulation of gene expression. Genes with at least 4 probes overlapping +/− 2Kb of TSS and P-value <=0.005 ordered according to gene expression fold change.

Gene Symbols	Gene Name	RefSeq Genes	Methylation Foldchange	Methylation P-value	Expression Foldchange	Expression P-value
Esm1	Endothelial Cell Specific Molecule 1	NM_023612	−1.3494	0.0000	16.1201	0.0000
Mmp12	Metallopeptidase 12	NM_008605	−1.2883	0.0091	7.5521	0.0031
Casp1	Caspase 1	NM_009807	−1.2671	0.0022	5.4685	0.0000
Casp12	Caspase 12	NM_009808	−1.2243	0.0054	5.1692	0.0000
Clec4a3	C-type lectin domain family 4, member a3	NM_001204241	−1.2085	0.0313	4.4933	0.0001
Cd48	CD48	NM_007649	−1.3816	0.0000	3.6570	0.0007
Lilr4b	Leukocyte immunoglobulin-like receptor, subfamily B, member 4B	NM_001291892 /// NM_001291893 /// NM_008147	−1.2219	0.0053	3.3254	0.0047
Cd34	CD34	NM_001111059 /// NM_133654	−1.2185	0.0011	3.3165	0.0231
Ctla2a	Cytotoxic T lymphocyte-associated protein 2α	NM_001145799	−1.2203	0.0006	3.3057	0.0087
Casp4	Caspase 4	NM_007609	−1.2271	0.0279	2.9870	0.0012
Ear12	Eosinophil-associated, ribonuclease A family, mem 12	NM_001012766	−1.3268	0.0050	2.9168	0.0003
Ear2	Eosinophil-associated, ribonuclease A family, member 2	NM_007895	−1.3419	0.0038	2.9168	0.0003
C1qc	Complement C1qC chain	NM_007574	−1.2026	0.0011	2.7334	0.0035
Sdcbp2	Syndecan binding protein 2	NM_145535	−1.2690	0.0028	2.6564	0.0001
Plek	Pleckstrin	NM_019549	−1.2298	0.0002	2.6347	0.0025
Gbp2b	Guanylate binding protein 2b	NM_010259	−1.2215	0.0026	2.6149	0.0041
Sema3b	Semaphorin 3B	NM_009153	−1.2184	0.0007	2.5364	0.0000
Sema3b	Semaphorin 3B	NR_111986	−1.2161	0.0010	2.5364	0.0000